Heart rate variability in sickle cell disease: a case report
DOI:
https://doi.org/10.55892/jrg.v9i20.3507Keywords:
Heart Rate Variability, Sickle Cell Disease, Autonomic DysfunctionAbstract
This study aimed to describe and analyze heart rate variability (HRV) parameters in two individuals with sickle cell disease (SCD) from the same family, both diagnosed with HbSS hemoglobinopathy. This is a descriptive case report based on continuous resting electrocardiographic recording, with RR interval analysis in the time and frequency domains. Variables such as mean RR interval, SDNN, RMSSD, pRR50, mean heart rate, LF, HF, and LF/HF ratio were evaluated. The results showed that both cases presented alterations suggestive of autonomic dysfunction, evidenced by elevated resting mean heart rate and reduced markers related to parasympathetic modulation. Case 1 showed higher RMSSD, pRR50, SDNN, and HF values, indicating better vagal modulation when compared to Case 2. In contrast, Case 2 presented a more pronounced reduction in parasympathetic indicators and a higher LF/HF ratio, suggesting greater sympathovagal imbalance and possible sympathetic predominance. These findings reinforce that individuals with SCD may present impairments in cardiac autonomic regulation, possibly associated with chronic hypoxia, inflammation, clinical complications, and individual treatment characteristics. It is concluded that HRV analysis may represent a promising complementary tool for the clinical monitoring of individuals with SCD, especially for the early identification of autonomic alterations and for the planning of preventive and therapeutic strategies.
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References
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