How can bioarchitecture improve the integration and the functionality of definitive skin grafts in burn patients or patients with complex wounds: an integrative review
DOI:
https://doi.org/10.55892/jrg.v9i20.3254Keywords:
bioarchitecture, skin graft, tissue engineering, burns, skin regenerationAbstract
Bioarchitecture has stood out in cutaneous tissue engineering due to its potential to improve tissue integration and graft functionality by seeking to reproduce structural and functional aspects of the skin. This study aimed to analyze the scientific evidence on the application of bioarchitecture to improve the integration and functionality of definitive skin grafts, especially in burn patients or patients with complex wounds. This is an integrative literature review, with searches conducted mainly in the PubMed database and complemented by additional searches using specific terms related to the topic, including publications in Portuguese and English between 2015 and 2025. After the stages of identification, screening, eligibility, and inclusion, 21 studies comprised the final sample. The included studies addressed biomaterials, scaffolds, dermal substitutes, vascularization strategies, and emerging technologies, with a predominance of experimental and preclinical studies, in addition to reviews and translational and clinical research. Overall, the findings indicated that these strategies have potential to promote cell adhesion and proliferation, angiogenesis, tissue integration, and improvement in functional and scar-related outcomes. It is concluded that bioarchitecture has relevant potential as a complementary approach to conventional skin grafts; however, more robust clinical studies are still needed to define its real impact on reconstructive practice.
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References
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